Prof. Ernesto FattorussoCurriculum Vitae
Date of birth: 24/10/1937
Degree: Chemistry (1960)
Current position: Full professor of Organic Chemistry
Academic career
1/11/1960 to 15/3/1962 – temporary assistant professor of organic chemistry at the faculty of Science, University of Naples “Federico II”
16/3/1962 to 31/10/1975 – permanent assistant professor of organic chemistry at the faculty of Science, University of Naples “Federico II”
"libera docenza" in chemistry of natural products (1968)
1/11/1975- nowadays – Full professor of organic chemistry, University of Naples “Federico II” until 31/10/1980 at the faculty of Science; since 1/11/1980 at the faculty of Pharmacy.
Institutional activity
Dean of the Faculty of Pharmacy from 1987 to 1990 and from 1997 to 2000.
Director of the Department of Chemistry of Natural Products (1986-87, 1990-94,2006/).
Director of the Interdepartmental Center of Instrumental Analysis (1994-97).
President of the scientific committee of the “Polo della Scienza e delle Tecnologie della Vita” at the University of Naples “Federico II”(2001/2004).
President of CTO at the faculty of Pharmacy, University of Salerno (1993-94).
Chairman of academic staff of Chemistry and Industrial Chemistry at the University of Naples (1977-80).
Scientific activity
The scientific activity, which is documented by 320 papers, deals with the following main topics:
1) Structure and biogenesis of melanins.
2) Chemistry of bioactive metabolites from marine organisms.
3) Chemistry of bioactive metabolites from Mediterranean flora.
Over the first decade of professor Fattorusso’s academic activity his scientific research dealt with the study of the structure and biogenesis of melanins. At the beginning professor Fattorusso’s research was focused on elucidating the structure of natural and biosynthetic eumelanins, getting information about the building blocks of these complex and heterogeneous molecules. Then, feomelanins from mammals and birds have been studied, thus giving an important contribute to the definition of their biogenesis. This study led also to define the nature of some building blocks of these feomelanins.
The second and major research topic deals with the isolation and structural determination of secondary bioactive metabolites from invertebrate marine organisms and from algae. Chemical structure of the new metabolites has been elucidated mainly through spectroscopic methods (1D and 2D NMR). The above research, which started in the late 60’s, is still in progress with goals that have changed in the years. Initially, novelty of structures and biogenesis guided the choice of metabolites to be investigated; recently, bioactive metabolites aroused his attention. Particularly, the following metabolites were studied:
1) Bioactive metabolites playing a primary biological role in the producing organism
2) Bioactive metabolites affecting the environment
3) Bioactive metabolites as potential lead compounds in drug discovery
Lately a structure-activity study has been undertaken on some of the most interesting pharmacological active compounds and on their derivatives. Such a study involves also the synthesis of structurally related compounds. In the course of the above research more than 400 compounds were isolated, including steroids, terpenes, carotenoids, alkaloids, glycolipids, etc.Representative compounds isolated from marine organisms
Nowadays the research deals with:
a) Chemistry of immuno-modulating glycolipids with anticancer activity from marine sponges and investigation on their mechanism of action.
b) Chemistry and mechanism of action of cytotoxic metabolites from Tunicates.
c) Chemistry and mechanism of action of endoperoxides with cytotoxic and antiprotozoarian activity from sponges.
d) Isolation and structure determination and quantitation of biotoxins responsible for toxic events by harmful algal blooms in the Mediterranean Sea. Study of the metabolism of marine biotoxins producing organisms (dinoflagellates and diatoms).
Over the last five years the chemistry of therapeutically active terrestrial plants of the Mediterranean flora was investigated. Significant results were achieved in the following fields:
1) Flavonoids and saponins from Allium.
2) Diterpenes active against multi-drug resistance from Euphorbiaceae
3) Diterpenes from plants employed in bitter liquors
4) Monoterpenes and sesquiterpenes with insect-repellent activity.
Research coordination activity
Since 1980, prof. Fattorusso has continuously been the national coordinator of Programmi di ricerca ministeriali sulla Chimica delle Sostanze Naturali (programmi MURST 40% and PRIN).
He has been coordinator of the project Sistema lagunare veneziano and of the UNINA partner of the European projects NOMATEC (2002-2004) and BIOTOXmarin and ANTIMAL (2005-2008).
From 2002 the research laboratories directed by Prof. E. Fattorusso have been recognized by the European Commission as centres for Marie Curie fellowships (training and host fellowships) with a four-year grant.Coordinator of the European Project NatPharma (2009-2011)
Membership of Centres of Excellence
Scientific Coordinator of Polo delle Sostanze Naturali, Centro Regionale di Competenza in Diagnostica e Farmaceutica Molecolari funded by EC, CNR, and Regione Campania.
Coordinator for the University of Naples Federico II at the Centro di ricerca interuniversitario per la progettazione e lo sviluppo dei farmaci – Siena
Conferences organization
Member of the organizing committee
IUPAC II International Symposium on the Chemistry of Marine Natural Products
VII International Symposium on the Chemistry of Marine Natural Products)
Chairman of the organizing committee
IV and V National Symposium on the Chemistry of Natural Compounds,
XI International Symposium on the Chemistry of Marine Natural Products, 2004.
Member of the Advisory Board
X International Symposium on the Chemistry of Marine Natural Products, (Okinawa 2001)
II, III and IV Italian-Spanish Symposium on Organic Chemistry
23th International symposium on the Chemistry of Natural Products (Florence, 2002)
Conferences and seminars
In the last 2 years he gave the following invited presentations at conferences:
1)P. Ciminiello, C. Dell’Aversano, E. Fattorusso and M. Forino Toxic Algal Outbreaks in Mediterranean Sea
1st Euro-Mediterranean Conference on Marine Natural Products
Sharm el Sheik (Egitto) 31 Ottobre-4 Novembre 20082)G. Corea, E. Fattorusso and V. Lanzotti
Jatrophane Diterpenes from Euphorbia spp. as Modulators of Multidrug Resistance in Cancer Therapy
International PSE Symposium on Natural Products in Cancer Therapy Napoli 23-26 Settembre 20083)E. Fattorusso, P. Ciminiello, C. Dell’Aversano, , M. Forino
Algal Toxins in an Environmental Health Perspective
ISEE 20O9 Dublino (Irlanda) 25-29 Agosto 2009and the following seminars:
1)E. Fattorusso
2° MARBEF Training Course on Chemical Methods in Marine Ecology.
Napoli 9- 12 Settembre 20082)E. Fattorusso Chimica dei prodotti naturali marini: Recenti risultati e nuove opportunità Dipartimento Di Chimica “G. Ciamician” – Universita’ Di Bologna Lezione Magistrale per l’Inaugurazione dell’Anno Accademico 29 Ottobre 2009
3) E. Fattorusso 1970-2010: A 40-Year-old feeling ith Marine Natural products MNP Gordon Conference Ventura, California (USA) 28 Febbraio- 5 Marzo 2010
Master schools
Professor of Chemistry of natural products in:
1) Master in Drug design, University of Pisa
2) Master in tropical marine biodiversity and bioactive compounds
University of Marche – ANCONA –Sam Ratulangi University – MANADO, INDONESIA
Editorial Activity
Editor of Steroids
Editorial Board of:
Marine Drugs
Chinese Journal of Natural Medicines
Awards
1) A. Quilico Award (Società Chimica Italiana, 2002)
2) Paul Scheuer Award (Akademie Gemeinnuetziger Wissenchaft - Erfurt, 2004).3)Paul Scheuer Award ( University of Honolulu Foundation, 2010)
Papers published in last four years
1.P. Ciminiello, C. Dell’Aversano, E, Fattorusso, M. Forino, S. Magno, F. Santelia and M. Tsoukatou
Investigation of the toxin profile of Greek mussels Mytilus galloprovincialis by liquid chromatography-mass spectrometry
Toxicon, 47, 174 (2006)2.V. Costantino, E. Fattorusso, C. Imperatore and A. Mangoni
Glycolipids from sponges. Part 17. Clathrosides and Isoclathrosides, Unique Glycolipids from the Caribbean Sponge Agelas clathrodes
J. Nat. Prod, 69, 73 (2006)3.E. Fattorusso, A. Romano, O. Taglialatela-Scafati, G. Bavestrello, P. Bonelli and B. Calcinai
Coelodiol and coeloic acid, ent-isocopalane diterpenes from the Indonesian sponge Coelocarteria cfr. singaporensis
Tetrahedron Letters, 47, 2197 (2006)4.G. Campiani, S. Gemma, M. De Angelis, B. P. Joshi, G. Kukreja, L. Savini, E.Fattorusso, O. Taglialatela-Scafati, C. Fattorusso
Novel Polycyclic compounds as antimalarial agents
Eur. Patent 06 005 306.3 (app 15/3/2006)5.G. Campiani, S. Gemma, M. De Angelis, B. P. Joshi, G. Kukreja, E.Fattorusso, C. Fattorusso
Antimalarial agents having polyaromatic strucuture
Eur. Patent 06 005 307.1 (app 15/3/2006)6.W.E.G. Muller, H. C. Schroeder, E. Fattorusso, M.L. Menna, A. Aiello and A. Giordano
Isolation Structure Determination, Synthesis and Bioactivity of Damipipecolin and Damituricin
Eur. Patent 06 005 564.7 (app. 17/3/2006)
7.P. Ciminiello, C. Dell’Aversano, E. Fattorusso, S. Magno, L. Tartaglione, M. Cangini, M. Pompei, F. Guerrini, L. Boni and R. Pistocchi
Toxin profile of Alexandrium ostenfeldii (Dinophyceae) from the Northern Adriatic Sea revealed by liquid chromatography-mass spectrometry
Toxicon, 47, 597 (2006)8.P. Ciminiello and E. Fattorusso
Bivalve Mollusks as Vectors of Marine Biotoxins involved in Seafood Poisoning
in Progress in Molecular and Subcellular Biology – Subseries Marine Molecular Biotechnology – Mollusks. Ed. G. Cimino, M. Gavagnin pagg. 53-82
Springer-Verlag Berlin Heidelberg 20069.F. Borrelli, V. Ascione, R. Capasso, A. A. Izzo, E. Fattorusso, O. Taglialatela-Scafati
Spasmolytic Effect of Boerhaavia diffusa Extracts. Isolation and Structure-Activity Relationships of Non-Prenylated Rotenoids
J. Nat. Prod., 69, 903 (2006)10.H. C. Schroeder, H. J. Breter, E. Fattorusso, H. Ushijima,M, Wiens, R. Steffen, R. Batel, and W E. G. Mueller
Okadaic Acid, an Apoptogenic Toxin for Symbiotic/Parasitic Annelids in the Demosponge Suberites domuncula
Applied and Environmental Microbiology, 72, (2006)11.P. Ciminiello. C. Dell’Aversano, E. Fattorusso, M. Forino, L. Grauso, S.Magno, F. Santelia, V.S. Moutsos. E. N. Pitsinos, E. A. Couladouros
Oxazinins from toxic mussels: isolation of a novel oxazinin and reassignment of the C-2 configuration of oxazinin-1 and -2 on the basis of synthetic models
Tetrahedron,62, 7738, (2006)12.P. Ciminiello, C. Dell’Aversano, E. Fattorusso, M. Forino, G. S. Magno, L. Tartaglione, C. Grillo and N. Melchiorre
The Genoa 2005 Outbreak. Determination of Putative Palytoxin inMediterranean Ostreopsis ovata by a New Liquid Chromatography Tandem Mass Spectrometry Method
Analytical Chemistry, 78, 7153-59 (2006)13. S. Gemma, G. Kukreja, C. Fattorusso, M. Persico, M. P. Romano, M. Altarelli,L. Savini, G. Campiani, E. Fattorusso, N. Basilico, D. Taramelli, V. Yardleye, and S. Butini
Synthesis of N1-arylidene-N2-quinolyl-and N2- acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains Bioorg. Med. Chem. Lett., 16,5384(2006)14.G. Basile, U. Benatti, S. Bruzzone, G. Damonte, A. De Flora, E. Fattorusso, L.Franco, L. Guida, O. Taglialatela-Scafati, E. Zocchi
Novel adenyl dinucleotides with antitumour activity and a method for preparing thereof
PCT Int. Appl. (2006), 45pp. CODEN: PIXXD2 WO 2006117735 A1 20061109 AN 2006:117735715.C. Fattorusso, G. Campiani, B. Catalanotti, M. Persico, N. Basilico,S.Parapini,D.Taramelli,C. Campagnuolo, E. Fattorusso, A. Romano, O.Taglialatela-Scafati
Endoperoxide Derivatives from Marine Organisms.1,2-Dioxanes of the Plakortin Family as Novel Antimalarial Agents
J. Med. Chem., 49, 7088 (2006)16.P. Ciminiello, C. Dell'Aversano, E. Fattorusso, M. Forino, L. Grauso, S. Magno, R. Poletti, L. Tartaglione DesulfoYessotoxins from Adriatic mussels. A New Problem for the Seafood Safety Control. Chem. Res. in Toxicol., 20, 95 (2007)
17.M. Laroche , C. Imperatore , L. Grozdanov , V. Costantino 1, A. Mangoni 1, U. Hentschel and E. Fattorusso Cellular localisation of secondary metabolites isolated from the caribbean sponge Plakortis simplex Marine Biology, 151, 1365-1373 (2007)
18.W. E. G. Muller, S. I. Belikov, O. V. Kaluzhnaya, S. Perovic´-Ottstadt, E. Fattorusso, H. Ushijima, A. Krasko1 and H. C. Schroder Cold stress defense in the freshwater sponge Lubomirskia baicalensis Role of okadaic acid produced by symbiotic dinoflagellates FEBS Journal, 274, 23 (2007)
19.S. Gemma, G. Campiani, S. Butini, G. Kukreja, B. P. Joshi, M. Persico, B. Catalanotti, E. Novellino, E. Fattorusso, V. Nacci, L. Savini, D. Taramelli, N. Basilico, G. Morace, V. Yardley and C. Fattorusso Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore. J. Med. Chem., 50, 595 (2007)
20.A. Aiello, E. Fattorusso, A. Giordano, M. Menna, C. Navarrete and E. Muñoz Clavaminols A-F, novel cytotoxic 2-amino-3-alkanols from the ascidian Clavelina phlegraea Bioorg. Med. Chem., 15, 2920 (2007)
21.A. Ahmed-Belkacem, S. Macalou, F. Borrelli, R. Capasso, E. Fattorusso, O. Taglialatela-Scafati, and A. Di Pietro Non-Prenylated Rotenoids, a New Class of Potent Breast Cancer Resistance Protein Inhibitors. J. Med. Chem., 50, 1933-8 (2007)
22.C. Fattorusso, E. Stendardo, G. Appendino, E. Fattorusso, P. Luciano, A. Romano, Orazio Taglialatela-Scafati Artarborol, a nor-Caryophyllane Sesquiterpene Alcohol from Artemisia arborescens. Stereostructure Assignment through Concurrence of NMR Data and Computational Analysis Org. Letters, 9, 2377 (2007)
23.E. Barile, E. Fattorusso, A. Ialenti, A. Ianaro and V. Lanzotti Paraliane and pepluane diterpenes as anti-inflammatory agents: First insights in structure-activity relationships. Bioorg. Med. Chem. Lett., 17, 4196 (2007)
24.A. Aiello, E. Fattorusso, A. Giordano, M. Menna, W. E.G. Müller, S. Perović-Ottstadt and H. C. Schröder Damipipecolin and damituricin, novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella damicornis Bioorg. Med. Chem., 15, 5877 (2007)
25.F. Guerrini, P. Ciminiello, C. Dell’Aversano, L. Tartaglione, E. Fattorusso, L. Boni, R. Pistocchi Influence of temperature, salinity and nutrient limitation on yessotoxin production and release by the dinoflagellate Protoceratium reticulatum in batch- cultures Harmful Algae, 6, 707 (2007)
26.G. Campiani, C. Fattorusso, G. Kukreja, B.P. Joshi, Bhupendra Prasad; E. Fattorusso, M. De Angelis Quinolin-4-ylhydrazine derivatives as antimalarial agent. PCT Int. Appl. (2007) CODEN: PIXXD2 WO 2007104695 A1 20070920
27.G. Campiani, S. Gemma, C. Fattorusso, G. Kukreja, B. P. Joshi, O. Taglialatela Scafati, L. Savini, M. De Angelis, E. Fattorusso, . Antimalarial agents having polyaromatic structure. PCT Int. Appl. (2007) CODEN: PIXXD2 WO 2007104696 A1 20070920
28.A.Aiello, A. Giordano, E. Fattorusso, M. Menna, H. C. Schroeder, W. E. G Mueller Isolation, structure determination, synthesis and bioactivity of damipipecolin and damituricin. PCT Int. Appl. (2007), CODEN: PIXXD2 WO 2007107319 A1 20070927
29.E. Fattorusso and O. Taglialatela-Scafati ed. Modern Alkaloids 665 pp. Publisher: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany (2007)
30.A. Aiello, E. Fattorusso, M. Menna and O. Taglialatela-Scafati Structure and Biosynthesis of Halogenated Alkaloids in Modern Alkaloids E. Fattorusso and O. Taglialatela-Scafati ed. Wiley-VCH Verlag GmbH & Co.KGaA, Weinheim, Germany (2007)
31.V. Costantino, C. de Rosa, E. Fattorusso, C. Imperatore, A. Mangoni, C. Irace, C. Maffettone, D. Capasso, L. Malorni, R. Palumbo, and C. Pedone Oreacerebrosides, New Bioactive Cerebrosides with a Triunsaturated Sphingoid Base from the Sea Star Oreaster reticulatus Eur. J. Org. Chem., 5277-5283 (2007)
32.P. Ciminiello, C. Dell’Aversano, E. Fattorusso, M. Forino, . Grauso, F. U. Santelia, L. Tartaglione, V. I. Moutsos, E. N. Pitsinos and E. A. Couladouros Stereo-structural determination of three oxazinins isolated from Adriatic mussels via a synthetic and NMR-based approach Eur. J. Org. Chem., 5434-5439 (2007)
33.P. Ciminiello, C. Dell’Aversano, E. Fattorusso, M. Forino, L. Grauso, L. Tartaglione, F. Guerrini, R. Pistocchi Spirolide toxin profile of Adriatic Alexandrium ostenfeldii cultures and structure elucidation of 27-hydroxy-13,19-didesmethyl spirolide C J. Nat. Prod., 70, 1878 (2007)
34.V. Costantino, E. Fattorusso, C. Imperatore, A. Mangoni, S, Freigang, L. Teyton Glycolipids from Sponges. 18. Corrugoside, a New Immunostimulatory alpha- Galactoglycosphingolipid from the Marine Sponge Axinella corrugata Bioorg. Med. Chem., 106, 2077 (2008)..
35.P. Ciminiello, C. Dell’Aversano, E. Fattorusso, M. Forino, L. Tartaglione, c. Grillo and N. Melchiorre Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak J. Am. Soc. Mass Spect., 9, 111 (2008)
36.P. Ciminiello and E. Fattorusso Yessotoxins. Chemistry, Metabolism, and Chemical Analysis in Seafood and Freshwater Toxins, L. M. Botana ed., pgg. 287-314 , CRC Press, Boca Raton, London, New York (2008)
37.V. Costantino, E. Fattorusso, C. Imperatore, A. Mangoni, R. Teta Terpioside from the Marine Sponge Terpios sp, the First Glycosphingolipid having an L-Fucofuranose Unit Eur. J. Org. Chem, in press. E. Fattorusso, A. Romano, O. Taglialatela-Scafati, M. J .Achmad, G. Bavestrello and C. Cerrano Xenimanadins A-D, a Family of Xenicane Diterpenoids From the Indonesian Soft Coral Xenia.sp.Tetrahedron, Tetrahedron, 64, 3141 (2008)
38.E. Fattorusso, A. Romano, O. Taglialatela-Scafati,M.J .Achmad, G.Bavestrello and C. Cerrano
Lobozoanthamine,aNew Zoanthamine-Type Alkaloid From the Indonesian Soft Coral Lobophytum sp.Tetrahedron Letters, 49, 2189 (2008).39. S. Gemma, G. Campiani, S. Butini, G. Kukreja, S. Sanna Coccone, B. P. Joshi, M. Persico, V. Nacci, I. Fiorini, E. Novellino, E. Fattorusso, O. Taglialatela-Scafati, L. Savini, D. Taramelli, N. Basilico, S. Parapini, G. Morace, V. Yardley, S. Croft, M. Coletta, S. Marini, and C. Fattorusso
Clotrimazole Scaffold as an Innovative Pharmacophore Towards Potent Antimalarial Agents: Design, Synthesis, and Biological and Structure–Activity Relationship Studies
J. Med. Chem., 51, 1278-1294 (2008)40. C. Fattorusso, G. Campiani, G. Kukreja, M. Persico, S. Butini, M. P. Romano, M. Altarelli, S. Ros, M. Brindisi, L. Savini, E. Novellino, V. Nacci, E.Fattorusso,S. Parapini, N. Basilico, D. Taramelli, V. Yardley, S. Croft, M.Borriello, and S. Gemma .Design, Synthesis, and Structure–Activity Relationship Studies of 4-Quinolinyl-and 9-Acrydinylhydrazones as Potent Antimalarial Agents
J. Med. Chem., 51, 1333-1343 (2008)
41.V. Costantino, E. Fattorusso, C. Imperatore, A. Mangoni,R. Teta Terpioside from the Marine Sponge Terpios sp,the First Glycosphingolipid having an L-Fucofuranose Unit
Eur. J. Org. Chem, 2130 (2008)42. E. Barile, M. Borriello, A. Di Pietro, A. Doreau, C. Fattorusso, E. Fattorusso,V. Lanzotti
Discovery of a new series of jatrophane and lathyrane diterpenes as potent and specific P-glycoprotein modulators.
Org. & Biomol. Chem. 10, 1756-1762 (2008)43. E. Fattorusso, A. Romano, F. Scala and O. Tagliatatela-Scafati
Simplexidine, a Alkylpyridinium Alkaloidfrom the Caribbean Sponge Plakortis simplex
Molecules, 13, 1465 (2008)44 V. Costantino, E. Fattorusso, C. Imperatore, A. Mangoni
J-Coupling Analysis for Stereochemical Assignments in Furanosides: Structure Elucidation of Vesparioside B, a Glycosphingolipid from the Marine Sponge Spheciospongia vesparia
J. Org. Chem., 73, 6158-6165 (2008).45. E. Basilico Bosisio E; Buelli F; Campiani G; Casagrande M; Castelli F; Coghi P; Corbett Y; Cortelezzi L; D'Alessandro S; Dell'Agli M; Esposito F; Fattorusso C; Fattorusso E; Finaurini S; Galli G V; Gemma S; Habluetzel A; Lucantoni L; Melato S; Monti D; Olliaro P; Omodeo-Sale F; Parapini S; Persico M; Rizzi M; Romeo S; Rossi F; Rusconi C; Sparatore A; Scafati O Taglialatela; van den Bogaart E; Taramelli D; Vaiana N; Yerbanga S
Old and new targets for innovative antimalarial compounds: the differentStrategies of the Italian Malaria Network.
Parassitologia 50, 133-6 (2008) .46.Dell'Aversano, J.A. Walter, I.A. Burton, D.J Stirling, E. Fattorusso and M.A. Quilliam, Michal Isolation and Structure Elucidation of New and Unusual Saxitoxin Analogues from Mussels.
47.E. Fattorusso, P. Luciano, A. Romano, O. Taglialatela-Scafati, G. Appendino,M. Borriello and C. Fattorusso.
J. Nat. Prod. , 71, 1518-23 (2008)
Stereostructure Assignment of Medium-Sized Rings through an NMR-Computational Combined Approach.Application to the New Germacranes Ketopelenolides C and D.
J. Nat. Prod. ACS ASAP. CODEN: JNPRDF ISSN:0163-3864. AN 2008:138134048.A. Aiello, E. Fattorusso, M. Menna, R. Vitalone, H. C. Schroeder and W. E. G. Mueller Mumijo Traditional Medicine: Fossil Deposits from Antarctica(Chemical Composition and Beneficial Bioactivity) eCAM,2008;doi:10.1093/ecam/nen072
49.M. Riccardi, F. Guerrinia, F. Roncarati, A. Milandri, M. Cangini, S. Pigozzi, E. Riccardi, A. Ceredi, P. Ciminiello, C. Dell’Aversano, E. Fattorusso, M. Forino, L. Tartaglione and R. Pistocchi Gonyaulax spinifera from the Adriatic sea: toxin production and phylogenetic analysis Harmful Algae, in press
50.E. Fattorusso, P. Luciano, A. Romano, O. Taglialatela-Scafati, G. Appendino,
M. Borriello and C. Fattorusso.
Stereostructure Assignment of Medium-Sized Rings through an NMR- Computational Combined Approach. Application to the New Germacranes Ketopelenolides C and D.
J. Nat. Prod. 71, 1988-1992 (2008)51. A. Aiello, E. Fattorusso, M. Menna, R. Vitalone, H. C. Schroeder and W. E. G. Mueller
Mumijo Traditional Medicine: Fossil Deposits from Antarctica(Chemical Composition and Beneficial Bioactivity)eCAM,2008; doi:10.1093/ecam/nen07252.M. Riccardi, F. Guerrini, F. Roncarati, A. Milandri, M. Cangini, S. Pigozzi, E. Riccardi, A. Ceredi, P. Ciminiello, C. Dell’Aversano, E. Fattorusso, M. Forino, L. Tartaglione and R. Pistocchi
Gonyaulax spinifera from the Adriatic sea: toxin production and phylogenetic analysis
Harmful Algae, 8, 279 (2009)53.E. Fattorusso, A. Romano, O. Taglialatela-Scafati, C. Irace, C. Maffettone,G. Bavestrello and C. Cerrano
Oxygenated Cembranoids of the Decaryiol Type From the Indonesian Soft Coral
LobophytumspTetrahedron, 65, 2898-2904 (2009)
54.V. Costantino, E. Fattorusso, C. Imperatore, A. Mangoni and R. Teta
Amphiceramide A and B, Novel Glycosphingolipids from the Marine Sponge Amphimedon compressa
Eur. J. Org. Chem., 2112 (2009)55.E. Fattorusso and O. Taglialatela-Scafati
Marine Antimalarials
Mar. Drugs, 7, 130 (2009)56.A. Aiello, E. Fattorusso, A. Giordano, M. Menna, C. Navarrete and E. Munoz
Clavaminols G–N, six new marine sphingoids from the Mediterranean
ascidian Clavelina phlegraea
Tetrahedron, 65, 4384 (2009)57.G. Corea. A. Di Pietro, C. Dumontet, E. Fattorusso and V. Lanzotti Jatrophane diterpenes from Euphorbia spp. as modulators of multidrug resistance in cancer therapy.
Phytochemistry Review, 8, 431 (2009)58.P. Ciminiello, B. Catalanotti, C. Dell'Aversano, C. Fattorusso, E. Fattorusso, M.Forino, L. Grauso, A. Leo and L. Tartaglione Full relative stereochemistry assignment and conformational analysis of 13,19-d idesmethyl spirolide C via NMR- and molecular,modeling-based techniques. A step towards understanding spirolide's mechanism of action.
Organic & Biomolecular Chemistry, 7, 3674-3681 (2009).59.P. Ciminiello, C. Dell' Aversano, E. Fattorusso and M. Forino. Recent developments in Mediterranean harmful algal events. In Editor(s):
Advances in Molecular Toxicology, ed. J. C. Fishbein, Elsevier B.V.,
Amsterdam, 3 1-41. (2009)60.V. Costantino, E. Fattorusso, A. Mangoni, C. Perinu, G. Cirino, L. De Gruttola and F. Roviezzo
Tedanol: A potent anti-inflammatory ent-pimarane di terpene from the Caribbean Sponge Tedania ignis
Bioorg. Med. Chem., 17, 7542 (2009)61. P. Ciminiello, C. Dell’Aversano, E. Dello Iacovo, E. Fattorusso, M. Forino, †L. Grauso, L. Tartaglione, C. Florio, P. Lorenzon, M. De Bortoli, A. Tubaro, M. Poli, G. Bignami |
Stereostructure and biological activity of 42-Hydroxy Palytoxin: a new palytoxin analog from Hawaiian Palythoa spp.
Chem. Res. in Toxicol, 22, 1851–1859 (2009)62.R. F. Angawi, B. Calcinai, C. Cerrano, H. A. Dien, E. Fattorusso, F. Scala and O. Taglialatela-Scafati
Dehydroconicasterol and Aurantoic Acid, a Chlorinated Polyene Derivative, from the Indonesian Sponge Theonella swinhoei
J. Nat. Prod., 72 , 2195-2198 (2009).63.F. Guerrini, L. Pezzolesi, A. Fellera, M. R., P. Ciminiello, C. Dell'Aversano, L. Tartaglione, E. Dello Iacovo, E. Fattorusso, M. Forino and R. Pistocchi
Comparative growth and toxin profile of cultured Ostreopsis ovata from the Tyrrhenian and Adriatic Seas
Toxicon, 55, 211-220 (2010).64.P. Ciminiello,C. Dell'Aversano,E. Fattorusso,M.Forino, L. Tartaglione, L.Boschetti, S. Rubini, M. Cangini, S. Pigozzi and R. Poletti
Complex toxin profile of Mytilus galloprovincialis from the Adriatic sea revealed by LC–MS
Toxicon, 55, 280-288 (2010)65.O.TaglialatelaScafati,E.Fattorusso, A. Romano,F.Scala,V.Barone, P. Cimino, E. Stendardo, B. Catalanotti, M. Persico, C. Fattorusso
Insights Into the Mechanism of Action of Plakortins, Simple 1,2-Dioxane Antimalarials
Organic & Biomolecular Chemistry, 8, 846 (2010)66.A. Aiello, E. Fattorusso, P. Luciano, M. Menna, C. Navarrete, E. Muñoz, F.Bonadies, M. Guiso, F. Sanasi, G. Cocco and R. Nicoletti
Synthesis of structurally simplified analogues of Aplidinone A, a pro-apoptotic marine thiazinoquinone
Bioorg. Med. Chem., 18, 719-727 (2010)67.A.Aiello,E.Fattorusso,C.Imperatore, M. Menna and W. E.G. Müller
Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii
Mar. Drugs, 8, 285 (2010)68.A.Aiello,E.Fattorusso,P.Luciano,M.Menna,R.Vitalone Polyaxibetaine, an Amino Acid Derivative from the Marine Sponge Axinella polypoidesJ. Nat. Prod, ACS ASAP. CODEN: JNPRDF ISSN:0163-3864. AN 2010:403919
